Medication can provide some relief. Not all pain can be cured.

It is safer to use as little medication as possible and to avoid medication that has serious side effects. All medications have some sort of side effect. I remember a professor telling me that if a medication doesn’t have a side effect, it doesn’t have an effect.

Medication can provide relief. Unfortunately, when it comes to chronic pain, medication can provide little to no relief, and, at most, moderate relief.

There are many classes of pain medications. Some of them may improve the pain enough to allow a restful sleep, which is essential in the management of chronic pain. 

Over the counter medications like:


Never use more than 4000mg (4g) per day. Consult with your health care provider and pharmacist about use. It may work better to use it regularly as getting on top of severe pain is harder than managing moderate pain.

Non-steroidal Anti-inflammatories (NSAIDs):

Asprin, Naproxen, Ibuprofen, Celebrex and Meloxicam. Anti-inflammatories, on the other hand, can be dangerous even with small doses. It depends on your body and your luck. Up to 6% of people can develop heart complications from an NSAID and they are more likely to upset your stomach, even cause ulcers. it can also raise blood pressure and other side effects.

If you are taking a preventative dose of daily Asprin, it may be negated by NSAIDs.



There are multiple medications that can be used for chronic pain. I cannot mention all their uses and side effects, but will say that I have found Topiramate helpful for chronic severe headaches and migraine and Gabapentin helps improve sleep in some patients and has been suggested to help fibromyalgia. 


Not all pain can be managed with NSAID or over the counter drugs. Severe pain requires a multimodal approach which may include opioid treatment. The new opioid guidelines and restrictions have led to patients in severe pain suffering unnecessarily. This an article from The Washington Post

Learn about harm reduction – 2018 Harm Reduction Client Survey.

There are tools that help patients and health care providers improve safety when it comes to prescribing opioids. DIRE ScoreCAGE questionnaire

Other Antiinflammatory Drugs 

Hydroxychloroquine is a pill used for malaria that can be used for severe arthritis with an inflammatory component. Can be used for psoriasis arthritis.

Many treatments for inflammatory arthritis like rheumatoid arthritis can be tried: like Methotrexate plus hydroxychloroquine plus and Sulfasalazines  before biologicals.

Always talk to your healthcare professional before taking medications.

Your pharmacist can be very helpful too.

There are instances when pain is moderate to severe where medication with side effects will have to be considered. I think there has to be a balance where the side effects of the pain have to be weighed against the side effects of medication. That is why it is so important that you are able to communicate your pain to your doctor/healthcare provider. Have the conversations necessary to make reasonable choices.

Here are some articles you may find interesting about medication and also the effects of not having adequate pain control Pain BC website

Different types of medications – Check with your healthcare provider: I can’t mention ALL THE DIFFERENT INDICATIONS AND SIDE EFFECTS.


Antidepressant drugs that in low doses are used for pain, rather than depression (To treat depression you need high doses of these drugs) These medications are also used for cancer pain: Amitriptaline, Nortriptaline, Venlafaxine, Prisiq.  Amitriptaline and Trazodone can help sleep and with good sleep you can have less pain.

Antidepressants can help chronic pain in some instances. Their sedating side effects can help you sleep and build restorative chemicals. Improved sleep helps you cope with the stress of chronic pain.
Many people with pain suffer from anxiety and depression either from the pain or maybe you have inherited depression from you parents, or have it because of stress.

How do antidepressants work?

Antidepressants can help pain:

Sometimes anxiety is so over-powering that depression is not noticed. If you would like to try anti-depressants but are very anxious, ask your doctor to consider a two week course of benzodiazepines to help you through the worst. After two weeks the side-effect of increased anxiety goes down and in six weeks the effect is usually noticeable.

Some people feel numb or “dead” on anti-depressants. I wonder if that is not because chronic pain or chronic stress has led to PTSD. Our brains then only feel alive in a state of chaos. On anti-depressants, the calm feelings make you feel uncomfortable as your brain seeks the energy and excitement of chaos. Check out  Stress Anxiety and PTSD

Antidepressants do not cause a physical addiction.  They do have side effects. Speak to your health care provider.

Serotonin can be found in medications other than antidepressants. If you take too much, you may develop toxicity

Speak to your health care provider if you have: tremors, increased reflexes, muscle spasms, dilated pupils, sweating, fast heart rate, increased breathing rate, agitation, over-excitement, restlessness, or confusion.


Opioids carry significant risk and should be reserved for people suffering from severe or moderate to severe pain. Consult your health-care provider and, if necessary, bring family members along to advocate for you if your pain is severe enough to warrant opioids.

Under-treatment of pain carries significant risks to individuals. Use forms to help communicate your pain. Forms relating to Pain

Buprenorphine and Methadone
Using the steps provided, it is possible to improve your quality of life, but if the pain is overwhelming, then medication may be needed to enable you to use the tools.

Activity helps – but remember pacing. Step 5 Pain and Pacing

Ideally find activities that you enjoy doing. When you are unable to manage activities due to pain, then your health-care provider should be your advocate. Use  Forms relating to Pain to ensure good communication if you need stronger medication, like  opioids. Browse through

Using forms ensures easier, quicker and more effective communication with your health-care provider. Your local library may be able to help you print the forms to hand to your health-care provider.